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Building a Better DNA Assembly Line
Technology Category
- Analytics & Modeling - Machine Learning
- Application Infrastructure & Middleware - Data Exchange & Integration
- Functional Applications - Product Lifecycle Management Systems (PLM)
Applicable Industries
- Chemicals
- Food & Beverage
- Life Sciences
Applicable Functions
- Product Research & Development
- Quality Assurance
Use Cases
- Predictive Quality Analytics
- Process Control & Optimization
- Remote Control
Services
- Cloud Planning, Design & Implementation Services
- Software Design & Engineering Services
- System Integration
The Challenge
Arzeda needed a more efficient and less error-prone method to construct plasmids for producing designer proteins. The existing process was slow, resource-intensive, and prone to errors. The company faced a choice: either hire additional personnel to develop a new solution from scratch or integrate proven technologies from trusted vendors into a seamless, high-throughput DNA assembly platform.
About The Customer
Arzeda is a biotechnology company that designs and creates proteins for various industries, including life sciences, food, and chemicals. The company focuses on delivering important molecules by testing thousands of protein-producing plasmids. Arzeda aims to provide cost-effective and sustainable production of value-added specialty chemicals and ingredients. The company leverages computational protein design to build novel enzymes and develop new pathways, unlocking new opportunities for specialty chemicals, advanced materials, and health and nutrition products.
The Solution
Arzeda opted to integrate proven technologies from trusted vendors to create a seamless, high-throughput DNA assembly platform. They combined Twist Bioscience’s high-quality DNA fragments, TeselaGen’s DNA assembly design and laboratory automation software, and Labcyte’s Echo Liquid Handler. This integrated solution increased productivity, reduced consumable use, generated more accurate plasmid designs, and lowered costs. Twist Bioscience’s silicon-based DNA synthesis platform quickly and affordably produced high-quality synthetic DNA, which Arzeda combined into plasmids using sophisticated DNA assembly methods. TeselaGen’s software automated the process of DNA assembly, determining the best way to put plasmids together and which DNA fragments should be synthesized by Twist. The Labcyte Echo Liquid Handler used sound waves to move nanoliter-sized liquid droplets, making the process more efficient and reducing costs.
Operational Impact
Quantitative Benefit
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