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Comsol > 实例探究 > Optimizing Hematology Analysis: When Physical Prototypes Fail, Simulation Provides the Answers
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Optimizing Hematology Analysis: When Physical Prototypes Fail, Simulation Provides the Answers

技术
  • 分析与建模 - 数字孪生/模拟
  • 分析与建模 - 预测分析
  • 功能应用 - 远程监控系统
适用行业
  • 医疗保健和医院
  • 生命科学
适用功能
  • 产品研发
  • 质量保证
用例
  • 数字孪生
  • 预测性维护
  • 远程资产管理
服务
  • 软件设计与工程服务
  • 系统集成
挑战
Laboratory tests, such as hematology analysis, influence up to 70 percent of critical decisions including hospital admittance, discharge, and treatment. The accuracy of these tests is crucial for patient outcomes. HORIBA Medical, a global supplier of medical diagnostic equipment, faced challenges in optimizing their hematology analysis equipment using physical prototypes alone. The complexity of the physical processes involved, such as high fluid velocity, pressure drop, heat transfer, and intense electric fields, made it difficult to achieve accurate measurements. Additionally, factors like particle trajectory and orientation through the micro-aperture system further complicated the accuracy of the impedance measurement system.
关于客户
HORIBA Medical is a worldwide supplier of medical diagnostic equipment, specializing in hematology and clinical chemistry. The company places a strong emphasis on research and development, investing 10 percent of its revenues into these activities. HORIBA Medical's products are used in critical laboratory tests that influence up to 70 percent of important medical decisions, such as hospital admittance, discharge, and treatment. The company aims to design systems capable of performing complex tests while making the results easier to interpret. Numerical simulation plays a crucial role in their R&D process, helping to ensure the accuracy and comprehensiveness of their diagnostic tests.
解决方案
HORIBA Medical turned to COMSOL Multiphysics® simulation software to optimize their hematology analysis equipment. The simulation allowed them to import CAD models directly into the software, enabling detailed analysis and optimization of the micro-aperture-electrode system used for impedance measurement. By simulating the complex physical processes within the device, such as fluid flow, electric fields, and heat transfer, they were able to develop a better understanding of how these factors interact. One key improvement was the implementation of hydrodynamic focusing, which uses sheath flow to control the sample rate inside the aperture and direct the sample flow along the central axis. This technique significantly reduced analysis errors caused by particle trajectory and orientation. The simulation results demonstrated that hydrodynamic focusing greatly improved the accuracy of particle measurement, making the device about twice as accurate as non-hydrofocused systems. These findings were validated through experimental comparisons, justifying the implementation of this technique in HORIBA's diagnostic equipment.
运营影响
  • Simulation allowed HORIBA Medical to optimize their hematology analysis equipment, improving the accuracy of critical diagnostic tests.
  • The use of COMSOL Multiphysics enabled detailed analysis of complex physical processes, such as fluid flow and electric fields, within the device.
  • Hydrodynamic focusing was implemented to reduce analysis errors caused by particle trajectory and orientation, significantly improving measurement accuracy.
数量效益
  • The hydrofocused device is about twice as accurate as the non-hydrofocused one.

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