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实例探究 > STATISTICA is helping the General University Hospital in Prague with clinical research of drug optimization

STATISTICA is helping the General University Hospital in Prague with clinical research of drug optimization

技术
  • 分析与建模 - 预测分析
  • 应用基础设施与中间件 - 数据交换与集成
  • 功能应用 - 远程监控系统
适用行业
  • 医疗保健和医院
适用功能
  • 商业运营
  • 质量保证
用例
  • 临床图像分析
  • 预测性维护
  • 远程病人监护
服务
  • 软件设计与工程服务
  • 系统集成
  • 培训
挑战
In connection with an efficient and highly successful patient treatment process, the GUH performed a clinical research study. One aspect of the research was clinical pharmacology (pharmacogenetics, pharmacokinetics, pharmacodynamics) at intensive care units, whose practical use for patients entails drug dosages (doses plus intervals) individualized and optimized for specific patients. One such example would be a child with a specific pathological condition requiring an individualized treatment mode, e.g., whole-body hypothermic treatment, or extracorporeal membrane oxygenation (ECMO), or haemodiafiltration (HDF). As a practice, this facility performs individual pharmacokinetics/pharmacodynamics (PK/PD) and therapeutic drug monitoring (TDM) for patients in all cases of treatment where the effect of a drug depends on dose, plasmatic concentration, and therapeutic range. Processing of primary data and assessment of a given drug’s effect and movement within the organism for a larger group of patients—e.g., in a population of critically ill newborns and children—require not only multidisciplinary cooperation, but also suitable software. Aside from this purpose, this software is also used for post-graduate level instruction, lectures, and high-quality professional publications. In the past, the GUH addressed these needs via outsourcing, which was shown to be inefficient and unsuitable as it involved working with suppliers who do not understand this field completely.
关于客户
The General University Hospital (GUH) in Prague is one of the largest healthcare facilities in the Czech Republic. It provides basic, specialized, and highly specialized medical treatment as well as nursing, outpatient, and diagnostic care for children and adults in all primary areas. It also provides comprehensive pharmaceutical care, including technically demanding preparation of cytostatic and sterile medical products. The hospital is known for its efficient and highly successful patient treatment processes, and it engages in clinical research studies to further enhance its medical services. The GUH is also involved in post-graduate level instruction, lectures, and professional publications, making it a significant contributor to the academic sector in healthcare.
解决方案
The GUH decided to find and implement software that can primarily help modify drug dosage, to put it simply. The goal is for patients to receive drug doses that correspond to their current ages, clinical conditions, and other factors such as genetic makeup. This requires sophisticated software that can model these variables and “recommend” drug dosage. All defined needs are met by STATISTICA Standard Cz from StatSoft CR, a regional StatSoft office in the Czech Republic. The GUH acquired STATISTICA in 2012. The software was installed quite easily during the course of one day by the hospital’s IT staff. Aside from minimum support requirements during installation, the StatSoft team also provided standard training as needed. Cooperation with the supplier was exemplary during both pre-implementation and implementation phases. The supplier’s representatives continue to be excellent partners in the area of client support and training activities, such as providing seminars in the area of statistics.
运营影响
  • The StatSoft software is currently performing a very significant role in the individualization and optimization of drugs intended for GUH patients and, subsequently, all patients in general.
  • The research system uses available parameters—the patient’s age, clinical condition, genetic makeup, and other variables—to create a treatment dosage proposal. Positive and negative changes in drug effects related to dosage and concentration are monitored.
  • Research includes the dosage program, patient individualization, and drug effects for extracorporeal blood circulation. The research is passed on to the State Institute for Drug Control (SÚKL), which performs correlation of research results and validation.
数量效益
  • Reduced patient treatment time.
  • Reduced drug acquisition costs.
  • Reduced hospitalization time for individuals.

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